BOSSLEVEL.EU

Valproat, Antiepileptika und Epilepsie · Kapitel 35 von 35

Quellenverzeichnis

3.892 Wörter · etwa 18 Min. Lesezeit · Stand: · Redaktion: · Inhaltsverzeichnis · Ganze Studie als Markdown

Vollständige Liste der 137 Quellen der Master-Quellenliste (Format: [ID] Autoren (Jahr): Titel. Journal. PMID/DOI). Titel in anderen Sprachen als Englisch oder Deutsch stehen im Original; soweit die Master-Liste eine deutsche oder englische Übersetzung in Klammern mitführt, ist sie im Titel enthalten. Quellen ohne PMID und DOI sind Behörden-, Presse- oder Fachgesellschaftsdokumente.

  • [s01] Asghar MA et al. (2026): Quantitative analysis and toxicological mechanisms of various male infertility inducers: a network meta-analysis and pharmacological approach. Reprod Toxicol. PMID 41354316; DOI 10.1016/j.reprotox.2025.109134.
  • [s02] Christensen et al. (2026): Risk of neurodevelopmental disorders associated with paternal use of valproate during spermatogenesis: a living meta-analysis-version 1. JNNP. PMID 42120066; DOI 10.1136/jnnp-2026-338454.
  • [s03] Deutsches Ärzteblatt (2026): Risiko einer väterlichen Valproat-Einnahme für Nachkommen unklar. Deutsches Ärzteblatt. ohne PMID/DOI.
  • [s04] Deutsches Ärzteblatt (2026): Valproat bei Vätern: Studie findet keinen Zusammenhang mit Entwicklungsstörung bei Kindern. Deutsches Ärzteblatt. ohne PMID/DOI.
  • [s05] Feng et al. (2026): Paternal Valproate Exposure and Offspring Neurodevelopmental Outcomes. Neurology. PMID 42617146; DOI 10.1212/WNL.0000000000218375.
  • [s06] Gong Z, He J, Feng Q, Liu D, Liu S (2026): Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases. Front Pharmacol. PMID 41693779; DOI 10.3389/fphar.2026.1765071.
  • [s07] Jebli L et al. (2026): The impact of common medications on male fertility: an updated systematic review. Andrology. PMID 42730591; DOI 10.1111/andr.70381.
  • [s08] Li J et al. (2026): Carbamazepine disrupts the hypothalamic-pituitary-testicular axis and induces hormonal imbalances and sperm damage through activating GABBR2 to inhibit AC/cAMP/PKA pathway. Biochem Pharmacol. PMID 41571204; DOI 10.1016/j.bcp.2026.117722.
  • [s09] Meng et al. (2026): Valproate Use by Fathers and Risk of Neurodevelopmental Disorders in Children. NEJM Evidence. PMID 41733407; DOI 10.1056/EVIDoa2500254.
  • [s10] Mishra S et al. (2026): Evaluation of the intergenerational effects of valproic acid and sodium butyrate on male reproductive parameters in the rat. Reprod Toxicol. PMID 42668046; DOI 10.1016/j.reprotox.2026.109336.
  • [s11] Peng et al. (2026): Sodium valproate at concentrations bracketing estimated seminal plasma levels impairs human sperm function in vitro through oxidative stress and mitochondrial dysfunction. Toxicology. PMID 42697408; DOI 10.1016/j.tox.2026.154582.
  • [s12] Razaz N et al. (2026): Risk of neurodevelopmental disorders associated with paternal use of valproate during spermatogenesis. J Neurol Neurosurg Psychiatry. PMID 41781215; DOI 10.1136/jnnp-2025-337441.
  • [s13] Visualingam K, Rajah R, Khoo CS, et al. (2026): Semen quality in men with epilepsy receiving anti-seizure medications: a case-control study (preprint). Research Square (preprint). DOI 10.21203/rs.3.rs-11021937/v1.
  • [s14] Alves M, Durães D, Santos C (2025): Valproate in Psychiatric Practice: Risks to Fertility and Future Generations. Acta Médica Portuguesa. PMID 39746314; DOI 10.20344/amp.22284.
  • [s15] Amer ME, Dardoor MA, Othman AI, El-Missiry MA (2025): Melatonin as a potential adjuvant to mitigate depakine-induced testicular damage in rats through its biological features. BMC Complementary Medicine and Therapies. PMID 40563113; DOI 10.1186/s12906-025-04969-w.
  • [s16] An K et al. (2025): Analysis of ASMs and male infertility using the FDA adverse event reporting system (FAERS). Front Public Health. PMID 41668863; DOI 10.3389/fpubh.2025.1738546.
  • [s17] ANSM / EPI-PHARE / CNAM (2025): Valproate et risques pour l'enfant à naître, mesures actualisées (6 novembre 2025). ANSM. ohne PMID/DOI.
  • [s18] Arora A, Maricar A, Owen C, Yap T (2025): Minds in Balance, Fertility at Risk: Epilepsy and ADHD Drugs' Hidden Impacts. Neurology (AAN-Kongressabstract). DOI 10.1212/WNL.0000000000210938.
  • [s19] Asghar et al. (2025): Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway. Redox Biology. PMID 40505349; DOI 10.1016/j.redox.2025.103685.
  • [s20] Britto DBLA, Dias FCR, Guimarães PO, da Silva RJ, da Silva AA, Alves LC, dos Santos FB, da Silva Júnior VA (2025): Subacute treatment of copaiba and white rosin essential oils using integrated biomarker responses on the reproductive system of Wistar rats exposed to valproic acid. Acta Biologica Brasiliensia 8(1). ohne PMID/DOI.
  • [s21] Colas S et al. (2025): Paternal Valproate Use and Neurodevelopmental Disorder and Congenital Malformation Risk in Offspring. JAMA Network Open. PMID 41212559; DOI 10.1001/jamanetworkopen.2025.42581.
  • [s22] Couper RG, Espino PH, Vicuna MP, Burneo JG (2025): Effects of antiseizure medications on sexual hormones and functions in males with epilepsy: A systematic review and meta-analysis. Epilepsia. PMID 40325998; DOI 10.1111/epi.18436.
  • [s23] DGfE, ÖGfE, Schweizerische Epilepsie-Liga (2025): Einsatz von Valproat bei Männern mit idiopathischer generalisierter Epilepsie (aktualisierte Stellungnahme). DGfE. ohne PMID/DOI.
  • [s24] Fréquence Médicale (rédaction) (2025): Fertilité masculine : risques minimes lors de la prise de valproate. Fréquence Médicale. ohne PMID/DOI.
  • [s25] Kobylarek D, Zakrys K, Gierszewska J, et al. (2025): The neuroendocrine puzzle of epilepsy and infertility: what are we missing?. Frontiers in Neurology. PMID 41323226; DOI 10.3389/fneur.2025.1658284.
  • [s26] Mbizvo GK et al. (2025): A retrospective cohort study of valproate and infertility in men with epilepsy or bipolar disorder using international health data. Nature Communications. PMID 40954165; DOI 10.1038/s41467-025-63469-0.
  • [s27] Nunes M et al. (2025): Effects of carbamazepine-exposure on rat epididymal sperm in parental (F0) and F1 generations. Reprod Toxicol. PMID 40609708; DOI 10.1016/j.reprotox.2025.108981.
  • [s28] Olstad EW et al. (2025): Paternal valproate use and impact of shared genetic susceptibility on child neurodevelopment. Sci Rep. PMID 41203668; DOI 10.1038/s41598-025-23377-1.
  • [s29] Shaneh M, Chahardori M, Talebpour Amiri F, Amani N, Shaki F (2025): Mitochondrial protection and anti-inflammatory effect of curcumin in inhibiting reproductive toxicity induced by sodium valproate in male mice. Iranian Journal of Basic Medical Sciences. PMID 40584447; DOI 10.22038/ijbms.2025.82254.17791.
  • [s30] Shojaei M, Nazemi S, Khazaei M, et al. (2025): Hormonal and histological impacts of valproate in PTZ-kindled male rats: a focus on 5HT1A receptors. Neuroscience Letters. PMID 40780638; DOI 10.1016/j.neulet.2025.138335.
  • [s31] Tan H, Luo L, Li W, Lan W, Chen Y, Huang G, Yang J, Xi X (2025): A pharmacovigilance study of drug-reduced male semen quality based on the FDA adverse event reporting system database. Andrology. PMID 38831673; DOI 10.1111/andr.13668.
  • [s32] University of Liverpool (2025): Study finds minimal male fertility impact from epilepsy drug. Pressemitteilung. ohne PMID/DOI.
  • [s33] University of Liverpool (2025): Press release on Mbizvo et al. 2025. University of Liverpool news. ohne PMID/DOI.
  • [s34] Vidal (rédaction) (2025): Exposition paternelle au valproate et troubles neurodéveloppementaux chez l'enfant : ce que nous apprend la récente étude EPI-PHARE. Vidal.fr. ohne PMID/DOI.
  • [s35] Abady MM, Jeong JS, Kwon HJ, Assiri AM, Cho J, Saadeldin IM (2024): The reprotoxic adverse side effects of neurogenic and neuroprotective drugs: current use of human organoid modeling as a potential alternative to preclinical models. Frontiers in Pharmacology. PMID 38948466; DOI 10.3389/fphar.2024.1412188.
  • [s36] Abu-Risha SE, Sokar SS, Elzorkany KE, Elsisi AE (2024): Donepezil and quercetin alleviate valproate-induced testicular oxidative stress, inflammation and apoptosis. International Immunopharmacology. PMID 38744177; DOI 10.1016/j.intimp.2024.112240.
  • [s37] AEMPS (2024): Nota informativa: recomendaciones sobre el uso de valproato en varones para evitar el posible riesgo de trastornos del neurodesarrollo en sus hijos tras la exposicion paterna. AEMPS (15 de enero de 2024). ohne PMID/DOI.
  • [s38] AIFA (2024): Rischio potenziale di disturbi del neurosviluppo in bambini nati da uomini trattati con medicinali contenenti valproato: il PRAC raccomanda misure precauzionali. Comunicato AIFA, 12 gennaio 2024. ohne PMID/DOI.
  • [s39] Asghar et al. (2024): Understanding the impact of valproate on male fertility: insights from preclinical and clinical meta-analysis. BMC Pharmacology and Toxicology. PMID 39334455; DOI 10.1186/s40360-024-00791-1.
  • [s40] Christensen J, Trabjerg BB, Dreier JW (2024): Valproate Use During Spermatogenesis and Risk to Offspring. JAMA Network Open. PMID 38833248; DOI 10.1001/jamanetworkopen.2024.14709.
  • [s41] Demarti C (2024): Valproate chez les hommes : la prescription par un spécialiste recommandée. Le Quotidien du Pharmacien. ohne PMID/DOI.
  • [s42] Deutsche Gesellschaft für Epileptologie, Vorstand (2024): Stellungnahme der Deutschen Gesellschaft für Epileptologie zu Valproat bei Männern. DGfE. ohne PMID/DOI.
  • [s43] European Medicines Agency (2024): Precautionary measures to address potential risk of neurodevelopmental disorders in children born to men treated with valproate medicines. EMA website. ohne PMID/DOI.
  • [s44] Garey JD, Damkier P, Scialli AR, et al. (2024): Paternal Valproate Treatment and Risk of Childhood Neurodevelopmental Disorders: Precautionary Regulatory Measures Are Insufficiently Substantiated. Birth Defects Res. PMID 39189597; DOI 10.1002/bdr2.2392.
  • [s45] Lacroix I (2024): Adverse drug reactions on male fertility. Thérapie. PMID 37973492; DOI 10.1016/j.therap.2023.10.009.
  • [s46] Zulassungsinhaber in Abstimmung mit EMA und BfArM (2024): Rote-Hand-Brief Valproat: Neue Maßnahmen in Bezug auf das mögliche Risiko für neurologische Entwicklungsstörungen bei Kindern von Vätern. AkdÄ / BfArM. ohne PMID/DOI.
  • [s47] AEMPS (2023): Valproato: evaluacion de la exposicion paterna y riesgo de alteraciones del neurodesarrollo en ninos. AEMPS (10 de agosto de 2023). ohne PMID/DOI.
  • [s48] AIFA / EMA (2023): Revisione EMA dei dati sull'esposizione paterna al valproato. Comunicato AIFA, 17 agosto 2023. ohne PMID/DOI.
  • [s49] Holtkamp M, May TW et al. (DGN) (2023): Erster epileptischer Anfall und Epilepsien im Erwachsenenalter (S2k-Leitlinie, Version 6.0). AWMF 030/041. ohne PMID/DOI.
  • [s50] Lesné L, Desdoits-Lethimonier C, Hug E, et al (2023): Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. PMID 37505509; DOI 10.1093/toxsci/kfad076.
  • [s51] Oyovwi MO, et al. (2023): Quercetin protects against levetiracetam induced gonadotoxicity in rats. Toxicology. PMID 37098359; DOI 10.1016/j.tox.2023.153518.
  • [s52] Sakai K, Hara K, Tanemura K (2023): Testicular histone hyperacetylation in mice by valproic acid administration affects the next generation by changes in sperm DNA methylation. PLoS One. PMID 36893188; DOI 10.1371/journal.pone.0282898.
  • [s53] Atli Eklioglu O, Ilgin S (2022): Adverse effects of antiepileptic drugs on hormones of the hypothalamic-pituitary-gonadal axis in males: A review. Toxicology. PMID 34800598; DOI 10.1016/j.tox.2021.153043.
  • [s54] Casale M et al. (2021): Psychiatric comorbidities, sexual health and neurodevelopmental outcomes of offspring in men with epilepsy. Epilepsy & Behavior. PMID 33243681; DOI 10.1016/j.yebeh.2020.107562.
  • [s55] Guo Y et al. (2021): A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy. BioMed Research International. PMID 34285917; DOI 10.1155/2021/6624101.
  • [s56] Tallon C, O'Donovan S, Delanty N (2021): Reversible male infertility with valproate use: A review of the literature. Epilepsy & Behavior Reports. PMID 34027381; DOI 10.1016/j.ebr.2021.100446.
  • [s57] Taubøll E, Isojärvi JIT, Herzog AG (2021): The interactions between reproductive hormones and epilepsy. Handbook of Clinical Neurology. PMID 34266590; DOI 10.1016/b978-0-12-819973-2.00011-3.
  • [s58] Tektemur A, Etem Onalan E, Kaya Tektemur N, Dayan Cinkara S, Kilincli Cetin A, Tekedereli I, Kuloglu T, Turk G (2021): Carbamazepine-induced sperm disorders can be associated with the altered expressions of testicular KCNJ11/miR-let-7a and spermatozoal CFTR/miR-27a. Andrologia. PMID 33372325; DOI 10.1111/and.13954.
  • [s59] Akorede GJ (2020): Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male Wistar rats. Toxicology Reports. PMID 32055450; DOI 10.1016/j.toxrep.2020.01.017.
  • [s60] Markoula S et al. (2020): An open study of valproate in subfertile men with epilepsy. Acta Neurologica Scandinavica. PMID 33378111; DOI 10.1111/ane.13311.
  • [s61] Osuntokun OS, Akinsomisoye SO, Olayiwola G, Adedokun KI, Oladokun OO (2020): Carbamazepine adversely altered the pituitary-testicular axis with resultant reproductive dysfunctions than levetiracetam or carbamazepine-levetiracetam adjuvant treatment in male Wistar rat. Andrologia. PMID 33126292; DOI 10.1111/and.13871.
  • [s62] Tomson T, Muraca G, Razaz N (2020): Paternal exposure to antiepileptic drugs and offspring outcomes: a nationwide population-based cohort study in Sweden. JNNP. PMID 32651245; DOI 10.1136/jnnp-2020-323028.
  • [s63] Watkins LV, Angus-Leppan H (2020): Valproate, sexual health, and men: A narrative review. Epilepsy & Behavior. PMID 31892466; DOI 10.1016/j.yebeh.2019.106835.
  • [s64] Ibi D et al. (2019): Paternal valproic acid exposure in mice triggers behavioral alterations in offspring. Neurotoxicology and Teratology. PMID 31654689; DOI 10.1016/j.ntt.2019.106837.
  • [s65] Li S, Chen J, Abdulaziz ATA, et al. (2019): Epilepsy in China: Factors influencing marriage status and fertility. Seizure. PMID 31382137; DOI 10.1016/j.seizure.2019.07.020.
  • [s66] Solomon R, Shvartsur R, Azab AN (2019): The association between psychotropic drug use and fertility problems among male subjects. J Psychiatr Pract. PMID 30633729; DOI 10.1097/PRA.0000000000000353.
  • [s67] Starck C, Nevalainen O, Auvinen A, Eriksson K (2019): Fertility and marital status in adults with childhood onset epilepsy: A population-based cohort study. Epilepsia. PMID 31121078; DOI 10.1111/epi.16018.
  • [s68] Пылаева О. А., Мухин К. Ю. (2019): Безопасность и переносимость противоэпилептической терапии: акцент на вальпроатах. Рос вестн детской неврологии. DOI 10.17650/2073-8803-2019-14-3-37-58.
  • [s69] Ocek L, Tarhan H, Uludag FI, et al (2018): Evaluation of sex hormones and sperm parameters in male epileptic patients. Acta Neurol Scand. PMID 29315457; DOI 10.1111/ane.12892.
  • [s70] Wu et al. (2018): The effects of oxcarbazepine, levetiracetam, and lamotrigine on semen quality, sexual function, and sex hormones in male adults with epilepsy. Epilepsia. PMID 29889310; DOI 10.1111/epi.14450.
  • [s71] Zhao et al. (2018): Effects of valproate on reproductive endocrine function in male patients with epilepsy: A systematic review and meta-analysis. Epilepsy & Behavior. PMID 29940375; DOI 10.1016/j.yebeh.2018.04.029.
  • [s72] Baysal M, Ilgin S, Kilic G, Kilic V, Ucarcan S, Atli O (2017): Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress. PLoS One. PMID 28419133; DOI 10.1371/journal.pone.0175990.
  • [s73] Drobnis EZ, Nangia AK (2017): Psychotropics and male reproduction. Adv Exp Med Biol. PMID 29256128; DOI 10.1007/978-3-319-69535-8_8.
  • [s74] Iamsaard S, Sukhorum W, Arun S, et al (2017): Valproic acid induces histologic changes and decreases androgen receptor levels of testis and epididymis in rats. Int J Reprod Biomed. PMID 28835938.
  • [s75] Pavone C, Giacalone N, Vella M, Urso L, Zummo L, Fierro B (2017): Relation between sexual dysfunctions and epilepsy, type of epilepsy, type of antiepileptic drugs: a prospective study. Urologia. PMID 28315500; DOI 10.5301/uro.5000222.
  • [s76] Spencer D (2017): Levetiracetam in Men With Epilepsy: Testosterone Is Left Alone But Sperm Count Is Paramount. Epilepsy Currents. PMID 28490999; DOI 10.5698/1535-7511.17.2.99.
  • [s77] Sukhorum W, Iamsaard S (2017): Changes in testicular function proteins and sperm acrosome status in rats treated with valproic acid. Reprod Fertil Dev. PMID 27511211; DOI 10.1071/RD16205.
  • [s78] Ceylan et al. (2016): Effects of levetiracetam monotherapy on sperm parameters and sex hormones: Data from newly diagnosed patients with epilepsy. Seizure. PMID 27494618; DOI 10.1016/j.seizure.2016.06.001.
  • [s79] Hamed SA (2016): The effect of epilepsy and antiepileptic drugs on sexual, reproductive and gonadal health of adults with epilepsy. Expert Review of Clinical Pharmacology. PMID 26934627; DOI 10.1586/17512433.2016.1160777.
  • [s80] Ourique GM et al. (2016): Resveratrol prevents oxidative damage and loss of sperm motility induced by long-term treatment with valproic acid in Wistar rats. Experimental and Toxicologic Pathology. PMID 27432062; DOI 10.1016/j.etp.2016.07.001.
  • [s81] Ourique GM et al. (2016): Protective effect of vitamin E on sperm motility and oxidative stress in valproic acid treated rats. Food and Chemical Toxicology. PMID 27424124; DOI 10.1016/j.fct.2016.07.011.
  • [s82] Verrotti A, Mencaroni E, Cofini M, et al. (2016): Valproic Acid Metabolism and its Consequences on Sexual Functions. Current Drug Metabolism. PMID 27000076; DOI 10.2174/1389200217666160322143504.
  • [s83] Власов П. Н. (2016): Эпилепсия у взрослых: гендерные коморбидные расстройства, применение вальпроатов. Эпилепсия и пароксизмальные состояния. DOI 10.17749/2077-8333.2016.8.1.043-049.
  • [s84] Asadi-Pooya AA, Farazdaghi M, Ashjazadeh N (2015): Effects of carbamazepine on semen parameters in men with newly diagnosed epilepsy. Iranian Journal of Neurology. PMID 26622983.
  • [s85] Goldberg-Stern H, Itzhaki T, Landau Z, de Vries L (2015): Endocrine Effects of Valproate versus Carbamazepine in Males with Epilepsy: A Prospective Study. Horm Res Paediatr. PMID 25792241; DOI 10.1159/000375374.
  • [s86] Hamed SA et al. (2015): Seminal fluid analysis and testicular volume in adults with epilepsy receiving valproate. Journal of Clinical Neuroscience. PMID 25636832; DOI 10.1016/j.jocn.2014.08.029.
  • [s87] Kose-Ozlece H et al. (2015): Alterations in semen parameters in men with epilepsy treated with valproate. Iranian Journal of Neurology. PMID 26622982.
  • [s88] Liu X, Zhang H, Tan M, Xu X, Wu C (2014): 卡马西平对健康及癫痫雄性大鼠生殖系统相关指标的影响 (Effects of reproductive system in experimental male rats with carbamazepine). 武警医学. ohne PMID/DOI.
  • [s89] Reis RM et al. (2013): Altered sexual and reproductive functions in epileptic men taking carbamazepine. Journal of Sexual Medicine. PMID 23057419; DOI 10.1111/j.1743-6109.2012.02951.x.
  • [s90] Xiaotian et al. (2013): Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy. Journal of Clinical Neuroscience. PMID 23938015; DOI 10.1016/j.jocn.2012.11.028.
  • [s91] Aldemir E, Akdeniz F, Altay AB, Arici S, Umul M, Aydin HH, Celebisoy M, Vahip S (2012): Valproate-associated reproductive hormone abnormalities: do bipolar men have the same risk as epileptic men?. Turk Psikiyatri Derg. PMID 23225122.
  • [s92] Lee SY, et al. (Korean Epilepsy Society) (2012): Prevalence of Treated Epilepsy in Korea Based on National Health Insurance Data. Journal of Korean Medical Science. DOI 10.3346/jkms.2012.27.3.285.
  • [s93] Cai YH, Wang H (2011): 丙戊酸钠对青春期癫癎女孩垂体促性腺激素影响的研究 (girls; not male evidence). 中国当代儿科杂志. ohne PMID/DOI.
  • [s94] Cansu A, Ekinci O, Serdaroglu A, et al (2011): Effects of chronic treatment with valproate and oxcarbazepine on testicular development in rats. Seizure. PMID 21169035; DOI 10.1016/j.seizure.2010.11.019.
  • [s95] Khan S, Ahmad T, Parekh CV, Trivedi PP, Kushwaha S, Jena G (2011): Investigation on sodium valproate induced germ cell damage, oxidative stress and genotoxicity in male Swiss mice. Reprod Toxicol. PMID 22001255; DOI 10.1016/j.reprotox.2011.09.007.
  • [s96] Verrotti A, Loiacono G, Laus M, et al. (2011): Hormonal and reproductive disturbances in epileptic male patients: emerging issues. Reprod Toxicol. PMID 21338669; DOI 10.1016/j.reprotox.2011.02.002.
  • [s97] Bairy L, Paul V, Rao Y (2010): Reproductive toxicity of sodium valproate in male rats. Indian Journal of Pharmacology. PMID 20711373; DOI 10.4103/0253-7613.64503.
  • [s98] Авакян Г. Н., Бадалян О. Л., Крикова Е. В., Чуканова А. С., Бурд С. Г. (2010): Репродуктивные нарушения у больных эпилепсией мужчин. Эпилепсия и пароксизмальные состояния. ohne PMID/DOI.
  • [s99] Aldemir E, Akdeniz F (2009): [Effects of valproate on male reproductive functions]. Turk Psikiyatri Derg. PMID 20013429.
  • [s100] de Oliva SU, Miraglia SM (2009): Carbamazepine damage to rat spermatogenesis in different sexual developmental phases. Int J Androl. PMID 18637155; DOI 10.1111/j.1365-2605.2008.00898.x.
  • [s101] Lofgren E, Pouta A, von Wendt L, et al. (2009): Epilepsy in the northern Finland birth cohort 1966 with special reference to fertility. Epilepsy & Behavior. PMID 18755292; DOI 10.1016/j.yebeh.2008.08.007.
  • [s102] Svalheim S et al. (2009): Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults. Epilepsy & Behavior. PMID 19716343; DOI 10.1016/j.yebeh.2009.07.033.
  • [s103] Гузева В. И., Гузева В. В., Гузева О. В. (2009): Связь уровня гормонов крови с частотой приступов у мальчиков с эпилепсией. Журн неврол психиатр им С. С. Корсакова. PMID 19938278.
  • [s104] Bauer J, Klingmüller D (2008): Welches Antiepileptikum für Männer mit Epilepsie? Eine kritische epileptologische und andrologische Übersicht. Der Nervenarzt. PMID 19023554; DOI 10.1007/s00115-008-2578-z.
  • [s105] Hayashi T, Miyata A, Yamada T, et al. (2008): The impact of commonly prescribed drugs on male fertility. Human Fertility. PMID 18608524; DOI 10.1080/14647270701739566.
  • [s106] Isojärvi J (2008): Disorders of reproduction in patients with epilepsy: antiepileptic drug related mechanisms. Seizure. PMID 18164216; DOI 10.1016/j.seizure.2007.11.007.
  • [s107] Valles-Antuña C, Fernandez-Gomez JM, Escaf-Barmadah S, Fernandez-Miranda MC, Villanueva-Gomez F, Fernandez-Gonzalez F (2008): Fisiopatologia y manejo de la disfuncion sexual en pacientes epilepticos (titulo traducido del resumen en ingles). Rev Neurol. PMID 18389462.
  • [s108] Vargas Soler JA, Carrizosa Moog J, Alfaro Velasquez JM, Balthazar Gonzalez V, Cornejo Ochoa JW, Cadavid AM, Jaramillo MC (2008): Alteraciones del desarrollo fisico y sexual en varones prepuberes y puberes con epilepsia, Hospital Universitario San Vicente de Paul, Medellin, Colombia, 2005-2006. Iatreia 21(3):219-228. ohne PMID/DOI.
  • [s109] Гузева В. И., Гузева В. В., Гузева О. В. (2008): Анализ уровней гормонов крови у мальчиков допубертатного и пубертатного возраста с эпилепсией, получавших различные противоэпилептические препараты. Журн неврол психиатр им С. С. Корсакова. PMID 19618713.
  • [s110] Железнова Е. В. и соавт. (2008): Монотерапия эпилепсии у женщин: психиатрические и нейроэндокринные аспекты. Журн неврол психиатр им С. С. Корсакова. PMID 19008851.
  • [s111] Shetty, Narayana (2007): The effects of carbamazepine on sperm morphology in wistar rats. Indian Journal of Physiology and Pharmacology. PMID 18341222.
  • [s112] Agarwal P, Mehndiratta MM, Antony AR, et al. (2006): Epilepsy in India: nuptiality behaviour and fertility. Seizure. PMID 16781171; DOI 10.1016/j.seizure.2006.04.005.
  • [s113] Artama M, Isojärvi JIT, Auvinen A (2006): Antiepileptic drug use and birth rate in patients with epilepsy - a population-based cohort study in Finland. Human Reproduction. PMID 16751648; DOI 10.1093/humrep/del194.
  • [s114] Hayashi T et al. (2005): Asthenozoospermia: possible association with long-term exposure to an anti-epileptic drug of carbamazepine. Int J Urol. PMID 15661067; DOI 10.1111/j.1442-2042.2004.00982.x.
  • [s115] Hayashi T et al. (2005): Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin. Scand J Urol Nephrol. PMID 16257847; DOI 10.1080/00365590500252688.
  • [s116] Herzog AG et al. (2005): Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. Neurology. PMID 16217052; DOI 10.1212/01.wnl.0000178988.78039.40.
  • [s117] Røste LS et al. (2005): Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy. European Journal of Neurology. PMID 15679699; DOI 10.1111/j.1468-1331.2004.00899.x.
  • [s118] Artama M et al. (2004): Birth rate among patients with epilepsy: a nationwide population-based cohort study in Finland. American Journal of Epidemiology. PMID 15155290; DOI 10.1093/aje/kwh140.
  • [s119] Bauer J et al. (2004): Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy. Neurology. PMID 14745061; DOI 10.1212/01.wnl.0000091866.48962.79.
  • [s120] Isojärvi JIT et al. (2004): Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology. PMID 14745062; DOI 10.1212/01.wnl.0000098936.46730.64.
  • [s121] Mikkonen K, Tapanainen P, Pakarinen AJ, Päivänsalo M, Isojärvi JI, Vainionpää LK (2004): Serum androgen levels and testicular structure during pubertal maturation in male subjects with epilepsy. Epilepsia. PMID 15230700; DOI 10.1111/j.0013-9580.2004.04604.x.
  • [s122] Balaguer Martinez JV, Lopez Garcia MJ, Andres Celma M, Contell Villagrasa A, Castello Pomares ML (2003): Efectos del valproato sobre el desarrollo sexual. An Pediatr (Barc). PMID 12724077; DOI 10.1016/s1695-4033(03)78091-6.
  • [s123] Roste LS et al. (2003): Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy. Eur J Neurol. PMID 12940829; DOI 10.1046/j.1468-1331.2003.00615.x.
  • [s124] Ban Y, Naya M, Nishimura K, et al. (2001): Collaborative study on rat sperm motion analysis using CellSoft Series 4000 semen analyzer. Journal of Toxicological Sciences. PMID 11255794; DOI 10.2131/jts.26.9.
  • [s125] Silveira DC, Souza EA, Carvalho JF, Guerreiro CA (2001): Interictal hyposexuality in male patients with epilepsy. Arq Neuropsiquiatr. PMID 11299426; DOI 10.1590/s0004-282x2001000100006.
  • [s126] Власов П. Н., Карлов В. А., Кушлинский Н. Е. (2001): Фармакологические и гормональные эффекты карбамазепина и вальпроевой кислоты при лечении женщин репродуктивного возраста с эпилепсией. Журн неврол психиатр им С. С. Корсакова. PMID 11765608.
  • [s127] Nishimura N, Sakai Y, Yonezawa S, et al. (2000): Effects of valproic acid on fertility and reproductive organs in male rats. Journal of Toxicological Sciences. PMID 10845186; DOI 10.2131/jts.25.85.
  • [s128] Silva HC, Carvalho MJ, Jorge CL, Cunha Neto MB, Goes PM, Yacubian EM (1999): Disturbios sexuais na epilepsia. Resultados de uma avaliacao multidisciplinar. Arq Neuropsiquiatr. PMID 10751915.
  • [s129] Soliman GA, Abd el-Meguid A (1999): Effects of antiepileptic drugs carbamazepine and sodium valproate on fertility of male rats. Dtsch Tierarztl Wochenschr. PMID 10220947.
  • [s130] Yerby MS, McCoy GG (1999): Male infertility: possible association with valproate exposure. Epilepsia. PMID 10219283; DOI 10.1111/j.1528-1157.1999.tb00752.x.
  • [s131] Olafsson E, Hauser WA, Gudmundsson G (1998): Fertility in patients with epilepsy: a population-based study. Neurology. PMID 9674781; DOI 10.1212/wnl.51.1.71.
  • [s132] Niwa K, Kitagawa Y, Yoshii F, et al. (1996): [Oligospermia improved by switching an anticonvulsant from phenytoin to valproate]. Rinsho Shinkeigaku. PMID 8741357.
  • [s133] Schupf N, Ottman R (1996): Reproduction among individuals with idiopathic/cryptogenic epilepsy: risk factors for reduced fertility in marriage. Epilepsia. PMID 8814095; DOI 10.1111/j.1528-1157.1996.tb00035.x.
  • [s134] Chen SS, Shen MR, Chen TJ, Lai SL (1992): Effects of Antiepileptic Drugs on Sperm Motility of Normal Controls and Epileptic Patients with Long-Term Therapy. Epilepsia 33(1):149-153. DOI 10.1111/j.1528-1157.1992.tb02298.x.
  • [s135] Бадалян Л. О., Тёмин П. А., Мухин К. Ю. (1991): Лечение андрогенами половых расстройств у мужчин с эпилепсией. Советская медицина. PMID 1871636.
  • [s136] PMDA (o. J.): 使用上の注意の改訂(バルプロ酸ナトリウム)別紙1. PMDA regulatory document. ohne PMID/DOI.
  • [s137] Santé sur le Net (rédaction) (o. J.): Faut-il aussi contre-indiquer le valproate chez l'homme ?. Santé sur le Net. ohne PMID/DOI.
Alle Kapitel und Anhänge (38)
  1. Das Wichtigste in Kürze
  2. Aufbau und Methodik dieser Studie
  3. 2.1 Epilepsie: Definition und Häufigkeit bis 2.5 Definitionen: Fertilität, Infertilität und die Ersatzendpunkte der Studien
  4. 2.6 Historie der Forschungsfrage bis Zusätzlich abgerufene Hintergrundquellen (nicht in der Quellenliste der Gesamtstudie)
  5. Überblick: Was an gepoolter Evidenz vorliegt bis Arora et al. 2025: Stimulanzien und Antiepileptika, systematische Übersicht (Kongressabstract) [s18]
  6. Die Evidenz zu väterlichem Valproat und kindlichen Entwicklungsstörungen: eine Living Metaanalyse und drei Registerstudien mit gepoolten Schätzern und Narrative Übersichtsarbeiten und Literaturübersichten ohne eigene Datenpoolung
  7. Gesamtschau: Was die gepoolte Evidenz trägt
  8. Gegenstand, Auswahlregel und Lesehilfe bis 2. Große Versorgungsdatenstudie zu Valproat und Infertilitätsdiagnosen
  9. 3. Prospektive Kohorten und Vorher-nachher-Studien mit Samenanalyse und 4. Querschnitts- und Fall-Kontroll-Studien mit Samenanalyse
  10. 5. Kontrollierte Studien zu Hormonen und Sexualfunktion und 6. Studien an Kindern und Jugendlichen
  11. 7. Kohortenstudien zu väterlicher Valproat-Exposition und Nachkommen und 8. Übergreifende Einordnung der Beobachtungsstudien
  12. 1. Prospektive Interventions- und Vorher-nachher-Studien am Menschen
  13. 2. Fallserien, Fallberichte und kleine klinische Beobachtungsreihen
  14. 3. Leitlinien, Stellungnahmen und Behördeninformationen
  15. 4.1 Gepoolte Nagerdaten: die präklinische Metaanalyse von Asghar et al. 2024 [s39] bis 4.5 Carbamazepin im Tiermodell
  16. 4.6 Levetiracetam im Tiermodell bis 4.9 Übersicht: Dosen und Übertragbarkeit
  17. 5. Einordnung der Evidenz dieses Kapitels und Lücken und nicht belegbare Punkte dieses Kapitels
  18. 1. Bewertungsraster für die Belegstärke bis 8. Entzündung und programmierter Zelltod
  19. 9. Direkte Schädigung von Hoden und Keimepithel bis 17. Gesamtübersicht: Belegstärke je Wirkweg
  20. 18. Offene Fragen zu den Mechanismen und 19. Grenzen dieses Kapitels
  21. 1. Dosis-Wirkung beim Menschen und 2. Zeitverlauf: Dauer der Einnahme und Verlauf der Befunde
  22. 3. Reversibilität bis 5. Fehlende Daten: eine offene Bestandsaufnahme
  23. 6. Zusammenfassende Bewertung
  24. Englisch und Deutsch
  25. Französisch bis Portugiesisch
  26. Spanisch
  27. Chinesisch
  28. Japanisch bis Russisch
  29. Arabisch und Türkisch
  30. Widersprüche und ihre mögliche Erklärung
  31. Limitationen der Evidenz
  32. Offene Forschungsfragen
  33. Praktische Einordnung
  34. Glossar
  35. Quellenverzeichnis
  36. Diagramme
  37. Quellen
  38. Prüfprotokoll der Quellenkontrolle