Mikrobiom und Probiotika · Kapitel 33 von 33

Quellenverzeichnis

Die Liste enthält alle 126 Quellen der Master-Quellenliste in der Reihenfolge der Kennungen (Jahr absteigend, dann Erstautor). Angaben zu Journal, PMID und DOI stammen aus der Master-Quellenliste; fehlt eine Angabe, ist sie dort nicht vorhanden. Titel nicht englischer Studien stehen im Original, eine deutsche Übersetzung folgt in Klammern.

[s001] Bazzar B., Reshadfar E., Namdar P., Pourbagher D., Bakhtiari Lafmejani R., Soleimanzadeh A., et al. (2026): The relationship between seminal microbiome and male reproductive wellness: a systematic review. Biology of Reproduction. PMID 41615012; DOI 10.1093/biolre/ioag003.

[s002] Boujemaa S et al. (2026): Impact of Mycoplasma hominis on sperm quality. Health Sci Rep. PMID 42011280; DOI 10.1002/hsr2.72412.

[s003] Buttà M, Sucato A, Capra G (2026): Unfolding the semen microbiota: implications for male infertility. Biomedicines. PMID 42512032; DOI 10.3390/biomedicines14071557.

[s004] Campbell KJ et al. (2026): Impact of male genital tract infections on semen quality. Fertil Steril. PMID 41825760; DOI 10.1016/j.fertnstert.2026.03.003.

[s005] Cannarella R, Curto R, Condorelli RA, et al. (2026): Relationship Between Seminal Microbiota and Sperm Parameters in Humans: A Prospective Cross-Sectional Study. Andrology. PMID 41185386; DOI 10.1111/andr.70140.

[s006] European Association of Urology (2026): Sexual and Reproductive Health guidelines, Male Infertility chapter (retrieved page truncated). EAU Guidelines. keine PMID/DOI in der Master-Quellenliste.

[s007] Gholipour F, Gharakhani D, Rahavian A, et al. (2026): Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial. Iranian Journal of Medical Sciences. PMID 41625341; DOI 10.30476/ijms.2025.105150.3888.

[s008] Harati R et al. (2026): Timing-dependent effects of prebiotic-probiotic supplementation on high-fat-diet-induced testicular dysfunction and gut microbiota alterations in rats. Microorganisms. PMID 42514071; DOI 10.3390/microorganisms14071566.

[s009] Kaltsas A., Pournaras S., Giannakodimos I., Markou E., Stavropoulos M., Papaharitou S., et al. (2026): Probiotics as microbiome modulators in male infertility: rethinking dysbiosis across the gut-testis axis. Journal of Personalized Medicine. PMID 41745391; DOI 10.3390/jpm16020099.

[s010] Kaltsas A, Pantazis N, Tzikoulis V, et al. (2026): Prostatitis-related male infertility: from inflammation and dysbiosis to sperm DNA damage. Diagnostics. PMID 41827997; DOI 10.3390/diagnostics16050722.

[s011] Kuribayashi S, Naik N, Miller AW, Lundy SD (2026): Micromanagement: how the male reproductive microbiome shapes male fertility. Fertil Steril. PMID 41611115; DOI 10.1016/j.fertnstert.2026.01.019.

[s012] Lee JH, Cho MC (2026): Impact of bacteriospermia on sperm DNA fragmentation: a narrative review. Transl Androl Urol. PMID 42293827; DOI 10.21037/tau-2026-1-0135.

[s013] Losacco C et al. (2026): Nutritional modulation of the gut-reproductive axis: multi-strain probiotic blend on oxidative and seminal parameters in healthy male dogs. Front Vet Sci. PMID 42109878; DOI 10.3389/fvets.2026.1820546.

[s014] Lu S et al. (2026): Interpretable machine learning uncovers core seminal microbial signatures in idiopathic oligoasthenospermia. Front Cell Infect Microbiol. PMID 42818602; DOI 10.3389/fcimb.2026.1923816.

[s015] Luo C et al. (2026): Functional remodeling of the gut microbiome and metabolome in primary idiopathic male infertility. BMC Microbiol. PMID 42026467; DOI 10.1186/s12866-026-05064-x.

[s016] Ma Y, Diao X, Wang Z (2026): Animal models of gut microbiota-male reproductive interactions: methodological assessment, translational bottlenecks, and optimization strategies. Front Endocrinol. PMID 42662544; DOI 10.3389/fendo.2026.1872670.

[s017] Melhem SJ, Melhem M, Haddad R, et al. (2026): Pharmacologic and nutritional therapies in idiopathic male infertility: a systematic review and meta-analysis. Andrology. PMID 42206761; DOI 10.1111/andr.70266.

[s018] Ngo C, Taechamaeteekul P, Boonprakob R, et al. (2026): Boar fecal and seminal microbiomes in relation to semen quality and probiotic supplementation in an antibiotic-free feeding program. Theriogenology. PMID 40839943; DOI 10.1016/j.theriogenology.2025.117637.

[s019] Ömür A.D., Çelebi D., Akarsu S.A., Apaydin Yildirim B., Uçak G., Acisu T.C., Aydin M.A., et al. (2026): Probiotic Supplementation as an Alternative to Antibiotics in Bovine Sperm Cryopreservation. Reproduction in Domestic Animals. PMID 41853987; DOI 10.1111/rda.70197.

[s020] Prihadi J.C., Hengky A., Alvianto S., Putranata H., Putra P.A., Telium H.D. (2026): Probiotic supplementation improved sperm parameters in idiopathic infertility male: a systematic review and meta-analysis. Urologia Colombiana. DOI 10.24875/ruc.25000029.

[s021] Retraction statement (2026): Retraction Statement: Probiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men. Human Fertility. PMID 42050763; DOI 10.1080/14647273.2026.2663617.

[s022] Shamsi-Goushki A, Mahmoodi M, et al. (2026): Effects of probiotics intervention on sperm parameters: A systematic review on literature. Nutrition and Health. PMID 42377322; DOI 10.1177/02601060261464829.

[s023] Shamsi-Goushki A, Mahmoodi MR, Ashourzadeh S, et al. (2026): Studienprotokoll: MIND-Diät und Probiotika bei übergewichtigen und adipösen Männern. Trials. PMID 42443988; DOI 10.1186/s13063-026-09891-1.

[s024] Sindi RA, Al-Samarai EAM, Abdelnour S, et al. (2026): Oral administration of a probiotic blend modulates immuno-antioxidant status, semen quality, cytokines, and endocrine profiles in rabbit bucks. Probiotics and Antimicrobial Proteins. PMID 42799965; DOI 10.1007/s12602-026-11231-3.

[s025] Tas GG et al. (2026): Probiotic and paraprobiotic intervention modulates testicular DNA methylation in streptozotocin-induced diabetic rats. Sci Rep. PMID 42310035; DOI 10.1038/s41598-026-54536-7.

[s026] Vougiouklaki D., Prountzou E., Siatelis A., Ladias K., Papaparaskevas M., Tsakali E., et al. (2026): Decoding the seminal microbial fingerprint and semen quality: insights from the first Greek pilot study. Frontiers in Microbiology. PMID 42293567; DOI 10.3389/fmicb.2026.1829292.

[s027] Yao G et al. (2026): Gut Bacteroidales and AMH/INH-B ratio predict sperm retrieval. Front Cell Infect Microbiol. PMID 42256217; DOI 10.3389/fcimb.2026.1777930.

[s028] Zarehoroki A, Vahidi S, Sahebnasagh A, et al. (2026): Synbiotic plus antioxidant in idiopathic oligoasthenoteratozoospermia. International Journal of Urology. PMID 41387285; DOI 10.1111/iju.70255.

[s029] Zengin G, Azkeskin K, Kar F (2026): From probiotics to postbiotics: microbial approaches in male reproductive health. Biological Diversity and Conservation. DOI 10.46309/biodicon.2026.1838383.

[s030] Zhang X et al. (2026): Trimethylamine N-oxide and impaired spermatogenesis in the gut-testis axis. Biology. PMID 42450625; DOI 10.3390/biology15131078.

[s031] Zheng JC et al. (2026): Chronic stress drives oligoasthenozoospermia via gut microbiota-vitamin-Sting1/Slc9c2 axis. Nat Commun. PMID 42103725; DOI 10.1038/s41467-026-72450-4.

[s032] Zhou X et al. (2026): The influence and mechanism of gut microbiota on spermatogenesis. Cell Biol Toxicol. PMID 41820677; DOI 10.1007/s10565-026-10168-1.

[s033] Amodio G et al. (2025): Specific types of male infertility are correlated with T cell exhaustion or senescence signatures. Nat Commun. PMID 39856063; DOI 10.1038/s41467-025-56193-2.

[s034] Asgari F et al. (2025): Ureaplasma urealyticum and Enterococcus faecalis in seminal fluid, Shiraz, Iran. Infect Disord Drug Targets. PMID 39995129; DOI 10.2174/0118715265328194250213114956.

[s035] Baud D, Peric A, Vidal A, et al. (2025): Genital microbiota in infertile couples. Reprod Biomed Online. PMID 40915037; DOI 10.1016/j.rbmo.2025.105056.

[s036] Chatzokou D, Tsarna E, Davouti E, Siristatidis CS, et al. (2025): Semen Microbiome, Male Infertility, and Reproductive Health. International Journal of Molecular Sciences. PMID 40003912; DOI 10.3390/ijms26041446.

[s037] Gupte S, Shah A, Kirdat K, et al. (2025): Successful conception following probiotic intervention in males with semen dysbiosis: a case series. Research Square (preprint). DOI 10.21203/rs.3.rs-6083315/v1.

[s038] Hofman J, Brenerova P, Borilova Linhartova P (2025): State-of-the-art approaches in the investigation of human seminal bacteriome using metagenomic methods. Front Reprod Health. DOI 10.3389/frph.2025.1557912.

[s039] Hu J et al. (2025): Morinda officinalis oligosaccharides improves sperm motility via the gut microbiota. Front Endocrinol. PMID 41561043; DOI 10.3389/fendo.2025.1711475.

[s040] Huerga López C, Sánchez Martín MJ, Herráez Moreta A, et al. (2025): Ligilactobacillus salivarius CECT5713 Increases Term Pregnancies in Women with Infertility of Unknown Origin: A Randomized, Triple-Blind, Placebo-Controlled Trial. Nutrients. PMID 40507130; DOI 10.3390/nu17111860.

[s041] Lu S et al. (2025): Comprehensive microbiome and metabolome analysis ... idiopathic oligoasthenozoospermia. Front Cell Infect Microbiol. PMID 41613599; DOI 10.3389/fcimb.2025.1741184.

[s042] Maleki-Hajiagha A, Karimi R, Abbasi S, et al. (2025): Vaginal probiotics as therapeutic adjuncts for improving embryo transfer success rates: a systematic review and meta-analysis. BMC Pregnancy and Childbirth. PMID 40057712; DOI 10.1186/s12884-025-07338-0.

[s043] Mowla S, Farahani L, Tharakan T, et al. (2025): Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility. eLife. PMID 40338640; DOI 10.7554/elife.96090.

[s044] Puerta-Suárez J, Cardona Maya WD (2025): Is Lactobacillus spp. beneficial in human semen? Systematic review. JBRA Assisted Reproduction. PMID 40674558; DOI 10.5935/1518-0557.20250023.

[s045] Shim YH, Jang J, Jung I, et al (2025): The impact of probiotics on testosterone synthesis in the TM3 cell line. Clin Exp Reprod Med. PMID 41287565; DOI 10.5653/cerm.2025.08095.

[s046] Фаниев М.В., Кадыров З.А., Прокопьев Я.В., Федоренко Т.В., Маркелова М.И., Хуснутдинова Д.Р., Григорьева Т.В. (2025): Сравнительный анализ микробиоты уретры и яичек у пациентов с обструктивной азооспермией с результатами вспомогательных репродуктивных технологий (Vergleichende Analyse der Mikrobiota von Harnröhre und Hoden bei Patienten mit obstruktiver Azoospermie und Ergebnisse der assistierten Reproduktion). Экспериментальная и клиническая урология. DOI 10.29188/2222-8543-2025-18-3-88-97.

[s047] Baud D, Zuber A, Peric A, et al. (2024): Impact of semen microbiota on the composition of seminal plasma. Microbiology Spectrum. PMID 38349179; DOI 10.1128/spectrum.02911-23.

[s048] Biocodex Microbiota Institute (2024): Мужское бесплодие: виноваты бактерии спермы? (Männliche Unfruchtbarkeit: Sind die Bakterien im Sperma schuld?). Biocodex Microbiota Institute (web). keine PMID/DOI in der Master-Quellenliste.

[s049] Corral-Vazquez C, Blanco J, Sarrate Z, Anton E (2024): Unraveling the intricacies of the seminal microbiome and its impact on human fertility. Biology (Basel). PMID 38534419; DOI 10.3390/biology13030150.

[s050] Grande G, Graziani A, De Toni L, Garolla A, Ferlin A (2024): Male Tract Microbiota and Male Infertility. Cells. PMID 39120306; DOI 10.3390/cells13151275.

[s051] Henkel R (2024): Leukocytospermia and/or Bacteriospermia: Impact on Male Infertility. Journal of Clinical Medicine. PMID 38792382; DOI 10.3390/jcm13102841.

[s052] Jung SJ, Kim YG, Lee SO, Chae SW (2024): Effects of Korean Versus Western Diets on Reproductive Function in Young Korean Men: A 12-Week Randomized Parallel Clinical Trial. J Lifestyle Med. PMID 38665320; DOI 10.15280/jlm.2024.14.1.20.

[s053] Lee EH, Kim YJ, Jung IS, Kim DK, Lee JH (2024): The Probiotics Lacticaseibacillus paracasei, Lacticaseibacillus rhamnosus, and Limosilactobacillus fermentum Enhance Spermatozoa Motility Through Mitochondrial Function-Related Factors. Int J Mol Sci. PMID 39684929; DOI 10.3390/ijms252313220.

[s054] Neto FTL, Viana MC, Cariati F, Conforti A, Alviggi C, Esteves SC (2024): Effect of environmental factors on seminal microbiome and impact on sperm quality. Front Endocrinol. PMID 38455659; DOI 10.3389/fendo.2024.1348186.

[s055] Oliveira L.C.S.L., Costa E.C., Martins F.D.G., Rocha A.S.D., Brasil G.A. (2024): Probiotics supplementation in the treatment of male infertility: A Systematic Review. JBRA Assisted Reproduction. PMID 38530761; DOI 10.5935/1518-0557.20240013.

[s056] Osadchiy V., Belarmino A., Kianian R., Sigalos J.T., et al. (2024): Semen microbiota are dramatically altered in men with abnormal sperm parameters. Scientific Reports. PMID 38212576; DOI 10.1038/s41598-024-51686-4.

[s057] Özyer K, Kemaneci S (2024): İnfertiliteye Yeni Bir Bakış Açısı: Mikrobiyota (Ein neuer Blick auf die Infertilität: Mikrobiota). İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. DOI 10.61399/ikcusbfd.1219405.

[s058] Saldarriaga Lopez YM, et al. (2024): The microbiota of sexual intercourse and its effect on prostatitis. Rev Int Androl. PMID 38735876; DOI 10.22514/j.androl.2024.006.

[s059] Wu et al. (2024): Mixed probiotics modulated gut microbiota to improve spermatogenesis in bisphenol A-exposed male mice. Ecotoxicol Environ Saf. PMID 38171106; DOI 10.1016/j.ecoenv.2023.115922.

[s060] Фаниев М.В., Кадыров З.А., Федоренко Т.В., Прокофьев Я.В., Водолажский Д.И., Синицына А.Р. (2024): Взаимосвязь микробиома и мастоцитоза тестикулярной ткани при азооспермии (Zusammenhang zwischen Mikrobiom und Mastozytose des Hodengewebes bei Azoospermie). Вестник урологии. DOI 10.21886/2308-6424-2024-12-3-97-105.

[s061] Фаниев М.В., Прокопьев Я.В., Фаустова К.В., Кадыров З.А., Водолажский Д.И., Маркелова М.И., Хуснутдинова Д.Р., Григорьева Т.В., Черепнев Г.В. (2024): Сравнительный анализ микробиоты ткани яичка и уретры у пациентов с азооспермией методом секвенирования нового поколения (NGS) (Vergleichende Analyse der Mikrobiota von Hodengewebe und Harnröhre bei Patienten mit Azoospermie mittels Sequenzierung der nächsten Generation). Андрология и генитальная хирургия. DOI 10.62968/2070-9781-2024-25-2-120-126.

[s062] Фаниев М.В., Кадыров З.А., Дружинина Н.К., Степанов В.С., Прокопьев Я.В., Федоренко Т.В., Маркелова М.И., Хуснутдинова Д.Р., Григорьева Т.В. (2024): Структура микробиоты фертильных и инфертильных пациентов с различными видами азооспермии (Struktur der Mikrobiota fertiler und infertiler Patienten mit verschiedenen Azoospermieformen). Экспериментальная и клиническая урология. DOI 10.29188/2222-8543-2024-17-2-36-44.

[s063] Akbari Nargesi E, Falahatkar B (2023): Dietary supplementation of multi-strain probiotic in male rainbow trout broodstock. Fish Physiology and Biochemistry. PMID 37002469; DOI 10.1007/s10695-023-01181-w.

[s064] Asadi M, Gholipour F, Rahavian A, Javanbakht M (2023): Effects of probiotic supplementation on semen parameters after varicocelectomy: a randomized controlled trial. Journal of Research in Medical Sciences. PMID 38152072; DOI 10.4103/jrms.jrms_392_23.

[s065] Campbell K, Suarez Arbelaez MC, Ghomeshi A, et al. (2023): Next-generation sequencing analysis of semen microbiome taxonomy in men with nonobstructive azoospermia vs. fertile controls: a pilot study. F&S Science. PMID 37321541; DOI 10.1016/j.xfss.2023.06.001.

[s066] Cao T., Wang S., Pan Y., Guo F., Wu B., Zhang Y., Wang Y., Tian J., Xing Q., Liu X. (2023): Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities. Frontiers in Microbiology. PMID 37293215; DOI 10.3389/fmicb.2023.1182320.

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[s072] Mahiddine FY, You I, Park H, Kim MJ (2023): Management of dog sperm parameters and gut microbiota composition with Lactobacillus rhamnosus supplementation. Vet Res Commun. PMID 36977954; DOI 10.1007/s11259-023-10116-y.

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[s091] Li P, Wei K, He X, et al. (2021): Vaginal probiotic Lactobacillus crispatus seems to inhibit sperm activity and subsequently reduces pregnancies in rat. Frontiers in Cell and Developmental Biology. PMID 34485291; DOI 10.3389/fcell.2021.705690.

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[s094] Zhao Q, Huang JF, Cheng Y, et al. (2021): Polyamine metabolism links gut microbiota and testicular dysfunction. Microbiome. PMID 34758869; DOI 10.1186/s40168-021-01157-z.

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[s096] Choi JB, Lee SJ, Kang SR, Lee SS, Choe HS (2020): Analysis of bacterial community using pyrosequencing in semen from patients with chronic pelvic pain syndrome: a pilot study. Transl Androl Urol. PMID 32420145; DOI 10.21037/tau.2020.02.05.

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Alle Kapitel und Anhänge (36)
  1. Das Wichtigste in Kürze
  2. Aufbau und Methodik dieser Studie
  3. 2.1 Männliche Unfruchtbarkeit: Definition und Häufigkeit bis 2.4 Messgrößen: Samenanalyse, WHO-Referenzwerte 2021 und Mikrobiomdiagnostik
  4. 2.5 Historie der Forschungsfrage und 2.6 Was aus dem Hintergrund für die folgenden Kapitel folgt
  5. Gegenstand, Abgrenzung und Lesehinweise bis Systematische Übersicht: Puerta-Suárez und Cardona Maya 2025 [s044]
  6. Metaanalyse: Campbell et al. 2026, Genitaltrakt-Infektionen und Samenqualität [s004] bis Systematische Übersicht: Corbett, Crosby und McAuliffe 2021, Probiotika bei Paaren mit Unfruchtbarkeit [s087]
  7. Metaanalyse: Maleki-Hajiagha et al. 2025, vaginale Probiotika vor Embryotransfer (Frauen) [s042] bis Lücken und Grenzen dieses Kapitels
  8. A. Sequenzierungsstudien am Ejakulat: Vergleiche nach Spermienqualität und Fruchtbarkeitsstatus
  9. B. Samenmikrobiom und Samenplasma: DNA-Integrität, Oxidationspotenzial, Stoffwechselprodukte und Methodenvergleich bis D. Paare und assistierte Reproduktion: Samen- und Scheidenmikrobiom gemeinsam betrachtet
  10. E. Azoospermie: Ejakulat und Hodengewebe und F. Besondere Populationen: Prostatitis, Beckenschmerz, sexueller Beginn und HIV
  11. G. Kultur- und PCR-Studien: Bakteriospermie und Genitalinfektionen bis I. Humanproben aus einer überwiegend tierexperimentellen Studie
  12. J. Zusammenschau der Beobachtungsstudien
  13. Quellenbasis und Lesehinweise bis Ernährungsintervention: Koreanische gegenüber westlicher Kost (Jung et al. 2024)
  14. Registrierte und laufende Vorhaben bis Tierversuche und experimentelle Studien
  15. Querschnittsbewertung der klinischen Evidenz und Lücken und nicht belegbare Punkte
  16. Lesehilfe: Wie die Belegstärke eingestuft wird bis 4. Oxidativer Stress und DNA-Integrität
  17. 5. Die Darm-Hoden-Achse: Barriere, Endotoxin und Immunsystem bis 10. Das Genitalmikrobiom des Paares
  18. 11. Warum ein Probiotikum wirken könnte: die vorgeschlagenen Wirkwege bis 16. Fazit des Kapitels
  19. Vorbemerkung: Was „Dosis“ hier bedeuten kann bis 3. Zeitverlauf
  20. 4. Altersgruppen bis 7. Was Dosis, Alter, Vorerkrankung und Zeit für klinische Endpunkte bedeuten
  21. 8. Wo Daten fehlen: Lückenübersicht bis 10. Hinweise zu Zahlenwidersprüchen in den Quellen
  22. Englisch und Deutsch
  23. Französisch bis Portugiesisch
  24. Spanisch
  25. Chinesisch und Japanisch
  26. Koreanisch und Russisch
  27. Arabisch und Türkisch
  28. Widersprüche und ihre mögliche Erklärung
  29. Limitationen der Evidenz
  30. Offene Forschungsfragen
  31. Praktische Einordnung
  32. Glossar
  33. Quellenverzeichnis
  34. Diagramme
  35. Quellen
  36. Prüfprotokoll der Quellenkontrolle