Hormonelle Fertilitätstherapie beim Mann · Anhang
Quellen s01–s133: Hormonelle Fertilitätstherapie beim Mann
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| ID | Autoren | Jahr | Titel | Journal | Design | Sprachräume | Link |
|---|---|---|---|---|---|---|---|
| s01 | Achermann APP, Pereira TA, Esteves SC | 2026 | Male Infertility in the 2025 WHO Infertility Guideline: A Comparative Analysis With AUA/ASRM, EAU, ESHRE, and NICE Recommendations | Andrology | Vergleichende Leitlinienanalyse (WHO, AUA/ASRM, EAU, ESHRE, NICE) | Englisch | PMID 42615963 |
| s02 | Al-Zubi M, Ghassab Deameh M, Awawdeh AK, Mohammad RJ, Shannaq AA, Qdisat SM, Mansi RM, Tanashat AY, Mubarak MA, Abu-Khadra B, Bani-Hani M | 2026 | Clomiphene citrate and human chorionic gonadotropin treatment before microdissection testicular sperm extraction in non-obstructive azoospermia: a retrospective non-randomized series | Frontiers in reproductive health | Retrospektive nicht randomisierte Serie · n=152 | Englisch, Arabisch | PMID 42088652 |
| s03 | Anfosso M, Schubert M, Cremers JF, Kliesch S, Zitzmann M, Bier S | 2026 | Can Hormonal Therapy Improve the Outcomes of mTESE in Patients With Non-Obstructive Azoospermia? | Andrology | Retrospektive Kohortenstudie · n=1256 | Englisch | PMID 42357925 |
| s04 | Anno Y, Tsujimura A, Kasai R, Ota Y, Kanda T, Wakita H, Ishikawa K, Taniguchi A, Uesaka Y, Nozaki T, Shirai M, Kobayashi K, Horie S. | 2026 | Efficacy and Safety of Clomiphene Citrate for Late-Onset Hypogonadism as Evaluated by Aging Male Symptom Rating Scale Over One Year. | International journal of urology : official journal of the Japanese Urological Association 33:e70289 | Retrospektive Kohorte · n=54 Männer | Englisch | PMID 41250569 |
| s05 | Bahceci T, Çeker G, Ceyhan E, Albaz AC, Duran MB, Özer C, Gül M | 2026 | Real-World Prescribing Patterns of Clomiphene Citrate for Male Infertility: A National Cross-Sectional Survey of Urologists in Türkiye | Journal of clinical medicine | Querschnittsbefragung (Umfrage unter Urologen) · n=402 | Englisch, Türkisch | PMID 42452476 |
| s06 | Bandura A, Ďurina P, Čambál E, Kečkéš Š | 2026 | Aromatase inhibitors as endocrine modulators: From breast cancer therapy to male off-label use and doping practice | The Journal of steroid biochemistry and molecular biology | Übersichtsarbeit | Englisch | PMID 42735742 |
| s07 | Barak S, Waldenberg N, Peretz A, Bartoov R, Bar G, Dekalo S | 2026 | Endocrine stimulation in men with non-obstructive azoospermia and low serum testosterone prior to micro-TESE: hormonal response as a predictor of sperm retrieval | The Canadian journal of urology | Retrospektive Studie · n=77 | Englisch | PMID 41800509 |
| s08 | Chandra V, Esteves SC, Sanagoudar S | 2026 | Gonadotropin therapy in idiopathic hypogonadal non-obstructive azoospermia (APHRODITE Groups 3-4): a multicenter randomized controlled trial | Frontiers in reproductive health | Studienprotokoll einer randomisierten Studie (keine Ergebnisse) | Englisch | PMID 42495163 |
| s09 | Clift AK, Johnson H, Huang DR, Ramasamy R | 2026 | Pituitary Axis Impacts and Effectiveness of Clomiphene and Human Chorionic Gonadotropin in Treating Hypogonadism: Cohort Study | The world journal of men's health | Retrospektive Kohortenstudie · n=6999 | Englisch | PMID 42402873 |
| s10 | Constantinou BT, Benedicto BC, Galligani L, Schiavon BN, Mendes CMO, Petri MMG, Uzueli B, Maia RS, da Sardenberg RAS, Fraietta R, Shiomi da Cruz JA | 2026 | Clomiphene citrate versus testosterone replacement therapy in male hypogonadism: a systematic review of literature and meta-analysis | European journal of clinical pharmacology | Systematische Übersicht und Metaanalyse · n=1512 | Englisch | PMID 42435198 |
| s11 | Dai C, Ding J, Zhang J, Zhu J, Fang Y, Wang C. | 2026 | Evaluation of male reproductive function after aromatase inhibitor treatment during adolescence: case series with literature review. | Journal of pediatric endocrinology & metabolism : JPEM 39:457-463 | Fallserie mit Literaturübersicht · n=10 Patienten (9 mit Samenprobe) | Englisch | PMID 41979040 |
| s12 | EAU Guidelines Panel on Sexual and Reproductive Health | 2026 | EAU Guidelines on Sexual and Reproductive Health (Abschnitt 11.5.3 Hormonal therapy) | European Association of Urology (Leitlinie, Webfassung) | Leitlinie (EAU) | Englisch | Link |
| s13 | Esteves SC, Humaidan P | 2026 | From tablets to targeted therapy: the APHRODITE era in male infertility | Human reproduction (Oxford, England) | Meinungsartikel | Englisch | PMID 41863283 |
| s14 | Esteves SC | 2026 | Hormonal Therapy Before Sperm Retrieval in Men With Non-Obstructive Azoospermia: From Controversy to Precision Using the APHRODITE Criteria | Reproductive medicine and biology | Narrative Übersichtsarbeit | Englisch | PMID 42494822 |
| s15 | Esteves SC, Viana MC, Achermann APP, Santi D | 2026 | Human chorionic gonadotropin-based clinical treatments for infertile men with non-obstructive azoospermia | Andrology | Übersichtsarbeit | Englisch | PMID 39901824 |
| s16 | Esteves SC | 2026 | The WHO 2025 Guideline for the Prevention, Diagnosis and Treatment of Infertility: A Comprehensive Review with Focus on Male Reproductive Health | International braz j urol : official journal of the Brazilian Society of Urology | Übersichtsarbeit zur WHO-Leitlinie 2025 (männliche Fertilität) | Englisch | PMID 41770990 |
| s17 | Gialouris JV, Conway AJ, Idan A, Savkovic S, Hermosilla R, Muir CA, Bacha F, Zhang T, Hou W, Jayadev V, Handelsman DJ | 2026 | Efficacy of Gonadotropin Therapy to Induce Spermatogenesis and Fertility in Men with Pathologic Gonadotropin Deficiency | The Journal of clinical endocrinology and metabolism | Kohortenstudie (konsekutive Patienten) · n=99 | Englisch | PMID 41165146 |
| s18 | Graziani A, Grande G, Scafa R, Selice R, Garolla A, Rocca MS, Vinanzi C, Ferlin A | 2026 | Pharmacogenetics of follicle-stimulating hormone action in the male | Andrology | Narrative Übersichtsarbeit (Pharmakogenetik) | Englisch | PMID 40304702 |
| s19 | Hamoda T, Shah R, Mostafa T, Pinggera GM, Atmoko W, Rambhatla A, Al Hashimi M, Çayan S, Colpi GM, Alipour H, Ko E, Zini A, Dimitriadis F, Rashed A, Park HJ, Saleh R, Toprak T, Ryzhkov A, Kadıoğlu A, Kandil H, Kalkanli A, El-Sakka AI, Calik G, Falcone M, Elbardisi H, Arafa M, Ho CCK, Martinez MP, Binsaleh S, Motawi AT, Gherabi N, Tsujimura A, Taniguchi H, Kosgi R, Calogero AE, Shatylko T, Kim D, Thomas C, Tadros NN, Andreadakis S, Musa MU, Konstantinidis C, Preto M, Le TV, Khalafalla KM, Cannarella R, Bowa K, Balagobi B, Katz DJ, Nguyen Q, Tanwar R, Borges Junior E, Agarwal A | 2026 | Global Andrology Forum (GAF) Clinical Guidelines on the Management of Non-obstructive Azoospermia: Bridging the Gap between Controversy and Consensus | The world journal of men's health | Konsensleitlinie (Delphi-Verfahren, Global Andrology Forum) | Englisch | PMID 40583014 |
| s20 | Hohl A, Lopes L, Ronsoni MF, Miranda EP, Fighera TM, Facio FN, Marchesan LB, Torres LO | 2026 | Care of Patients with Male Hypogonadism: A Joint Position Statement from the Brazilian Society of Endocrinology and Metabolism (SBEM), the Brazilian Society of Urology (SBU), and the Brazilian Association for Sexual Medicine and Health (ABEMSS) | International braz j urol : official journal of the Brazilian Society of Urology | Konsenspapier/Leitlinie (brasilianische Fachgesellschaften, männlicher Hypogonadismus) | Englisch, Portugiesisch | PMID 41678706 |
| s21 | Huijben M, Prinsen A, de Kort L, van Breda J | 2026 | Boosting Male Fertility: The Impact of Gonadotropin Therapy on Hypogonadotropic Hypogonadism-A Systematic Review and Meta-Analysis | Andrology | Systematische Übersicht und Metaanalyse · n=1583 | Englisch | PMID 41987691 |
| s22 | Huijben M, Prinsen AMA, de Keyser CE, van der Leij SM, Peeters EFHI, Stades AME, Tanahatoe SJ, de Kort LMO, van Breda HMK | 2026 | Therapeutic benefits of gonadotropins in male hypogonadotropic hypogonadism: a focus on spermatogenesis and fertility | Reproduction & fertility | Retrospektive Kohortenstudie (monozentrisch) · n=35 | Englisch | PMID 42189927 |
| s23 | Kaltsas A | 2026 | Micro-TESE in Non-Obstructive Azoospermia: Phenotype-Guided Hormonal Optimization and Testosterone Response-Prognostic Biomarker or Therapeutic Target? | Journal of clinical medicine | Narrative Übersichtsarbeit | Englisch | PMID 42589909 |
| s24 | Konnyu K, Imamura M, Hudson J, Swingler J, Manson P, Bhattacharya S, Jayasena CN, Brazzelli M | 2026 | The effectiveness of hormonal treatment to improve reproductive outcomes in normogonadotropic men with abnormal semen parameters: results of 2 linked systematic reviews | The Journal of clinical endocrinology and metabolism | Systematische Übersicht und Metaanalyse (zwei verknüpfte Reviews) · n=735 | Englisch | PMID 42030403 |
| s25 | Konsam BD, Bhadada SK, Dutta P, Gorsi U, Baruah MM, Prasad TN, Walia R | 2026 | Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial | Frontiers in endocrinology | Randomisierte offene Studie · n=45 | Englisch | PMID 41993983 |
| s26 | Lin CW, Huang EY, Huang WJ, Huang IS. | 2026 | Incidence and risk factors of low testosterone in infertile men with normal sperm concentration. | Frontiers in endocrinology 17:1797678 | Retrospektive Kohorte · n=3147 Männer, davon 718 mit Hormonuntersuchung, 66 behandelt | Englisch | PMID 42147113 |
| s27 | Melhem SJ, Melhem M, Haddad R, Alghurabi O, Mousa R, Massad E, Almomani H, Alrashdan Y, Melhem J | 2026 | Pharmacologic and Nutritional Therapies in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis | Andrology | Systematische Übersicht und Metaanalyse (RCT) · n=3615 | Englisch | PMID 42206761 |
| s28 | Pozzi E, Luca S, Birolini G, Raffo M, Negri F, Corsini C, Bertini A, Boeri L, Oddo M, Pagliardini L, d'Arma A, Montorsi F, Salonia A | 2026 | Outcomes and Predictors in Hypogonadal Oligospermic Men Treated with Clomiphene Citrate | The world journal of men's health | Retrospektive Kohortenstudie · n=166 | Englisch | PMID 42533482 |
| s29 | Roque C, Ko Y, Fidel MG, Shah J, Marzban SM, Dhillon H, Almuhanna A, Sarcar A, Patel P | 2026 | Effectiveness of clomiphene citrate on total motile sperm count and hormonal profile in men with clinical infertility | Canadian Urological Association journal = Journal de l'Association des urologues du Canada | Retrospektive Kohortenstudie · n=60 | Englisch | PMID 41848536 |
| s30 | Sun Y, Yao C, Liu G, Li Z, Yang X, Chen Q, Ye Z, Li H, Qu X, Guo H, Yang J, Wang T, Liang G, Zhu X, Lu Y, Chen W, Zhang F, Tian R, Zhi E, Chen H, Zhao F, Bai F, Sun H, Zhang J, Bu X, Qian D, Wu S, Qiu Y, Li Z, Li P | 2026 | Letrozole and Infertility Among Males With Spermatogenic Failure: A Randomized Clinical Trial | JAMA network open | Randomisierte klinische Studie (multizentrisch, offen) · n=296 | Englisch | PMID 42313386 |
| s31 | Tadisina S, Cristiano E, Wiegmann T, Grasing K, Drees B, Sharma R, Garcia-Touza M | 2026 | Testosterone Versus Clomiphene Treatment of Hypogonadism: A Retrospective Analysis in US Veterans | Andrology | Retrospektive Registeranalyse (Propensity-Matching) | Englisch | PMID 42015850 |
| s32 | Wang H, Chang H, Zhao Y, Wu S, Luo D, Sun D. | 2026 | Treatment Options for Improving The Semen Quality in Obese Men: A Scoping Review. | Journal of multidisciplinary healthcare 19:582182 | Scoping Review · n=28 klinische Studien | Englisch | PMID 41883587 |
| s33 | World Health Organisation Guideline Development Group for Infertility, Mburu G, Santesso N, Brignardello-Petersen R, Kennedy R, Farquhar C, Boivin J, Pennings G, Giudice LC, Rebar RW, Gianaroli L, Vuong LN, Esteves SC, De Jonge CJ, Pacey A, Ombelet W, Kucuk T, Collura BL, Kordic K, Amato P, Matsaseng T, Kiarie J | 2026 | Recommendations from the WHO guideline for the prevention, diagnosis, and treatment of infertility† | Human reproduction (Oxford, England) | Leitlinie (WHO 2025 zur Infertilität) | Englisch | PMID 41312724 |
| s34 | Zachariou A, Zikopoulos A, Markou E, Koukos S, Daligaros G, Skouros S, Dimitriadis F, Chrisofos M, Sofikitis N, Kaltsas A | 2026 | Fertility Outcomes in Men with Nonobstructive Azoospermia Due to Hypogonadotropic Hypogonadism After Gonadotropin Therapy | Journal of clinical medicine | Retrospektive Kohortenstudie · n=35 | Englisch | PMID 41682884 |
| s35 | Abdelnaby EA, Alhaider AK, Emam IA | 2025 | Effect of repeated injection of human chorionic gonadotropin on semen quality, testicular hemodynamics and hormonal profile of senile camel. | Veterinary research communications | Tierversuch (Kamel, veterinär) · n=10 | Arabisch, Englisch | PMID 40911138 |
| s36 | Ahmad A, Roy B, Babelay G, Dheeraj K | 2025 | Prospective Assessment of Gonadotropin Therapy and Its Outcome in Nonobstructive Azoospermic Patients | Cureus | Prospektive einarmige Beobachtungsstudie · n=20 | Englisch | PMID 40519431 |
| s37 | Berköz M, Yalın S, Türkmen Ö | 2025 | Protective roles of some natural and synthetic aromatase inhibitors in testicular insufficiency caused by Bisphenol A exposure. | International journal of environmental health research | Tierversuch (Ratte) · n=k. A. im Abstract | Türkisch, Englisch | PMID 38825800 |
| s38 | Cho MC, Lee H, Kim SW. | 2025 | Induction of Spermatogenesis and Its Predictors in Men with Prepubertal-Onset Hypogonadotropic Hypogonadism Undergoing Gonadotropin Therapy. | The world journal of men's health 43:992-1001 | Retrospektive Kohorte · n=65 Männer (50 ausgewertet) | Englisch | PMID 40878119 |
| s39 | Epanchintseva E A, Selyatitskaya V G | 2025 | [Typical patient models for conservative therapy of male infertility. Pathogenetic approaches and expected effects]. (deutsch: Typische Patientenmodelle für die konservative Therapie der männlichen Infertilität. Pathogenetische Ansätze und erwartete Wirkungen) | Urologiia (Moscow, Russia : 1999) | Übersichtsarbeit · n=k. A. | Russisch | PMID 40377588 |
| s40 | Essam M, ElSayed MAI, Youssef FS et al. | 2025 | Effect of administration of nanoparticles of human chorionic gonadotropin on testicular hemodynamics, testicular volume, testicular echotexture, and circulating testosterone and nitric oxide in pubescent goat bucks under heat stress conditions. | Veterinary research communications | Tierversuch (Ziegenbock, veterinär) · n=15 | Arabisch, Englisch | PMID 39812902 |
| s41 | Guedes J, Pla I, Sanchez A, Marko-Varga G, Domont GB, Sahlin KB, Hazir B, Giwercman A, Sousa Nogueira FC, Malm J, Lundberg Giwercman Y | 2025 | Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men | Endocrine connections | Randomisierte Studie (Proteom/Metabolom, vorübergehend medikamentös kastrierte Männer) · n=33 | Englisch | PMID 39745472 |
| s42 | Hashimi MA, Pinggera GM, Shah R, Agarwal A | 2025 | Clinician's guide to the management of azoospermia induced by exogenous testosterone or anabolic-androgenic steroids | Asian journal of andrology | Übersichtsarbeit | Englisch | PMID 39820213 |
| s43 | Hochu G, Geyer-Kim I, Kim E | 2025 | Preserving spermatogenesis in testosterone deficiency: innovations in replacement and stimulatory therapies | Translational andrology and urology | Übersichtsarbeit | Englisch | PMID 41522318 |
| s44 | Hohl A, Chavez MP, Pasqualotto E, Ferreira ROM, Sande-Lee SV, Ronsoni MF | 2025 | Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials | Archives of endocrinology and metabolism | Systematische Übersicht und Metaanalyse (RCT) | Englisch | PMID 41066380 |
| s45 | Huang IS, Li LH, Chen WJ, Juan CC, Huang WJ. | 2025 | Intratesticular Testosterone and Its Precursors among Azoospermic Men: A Pilot Study. | The world journal of men's health 43:142-153 | Pilotstudie · n=37 Proben (5 OA, 32 NOA) | Englisch | PMID 38772536 |
| s46 | Jiang H, Li BJ, Jin DC, Zhong QL, Zhu T, Li YF | 2025 | Therapeutic effects of a pulsatile GnRH pump on adult male patients with congenital hypogonadotropic hypogonadism (CHH): a retrospective study | Translational andrology and urology | Retrospektive Studie · n=54 | Englisch | PMID 40800099 |
| s47 | Kara E, Decourtye J, Dupuy L, Casteret S, Bouchard P, Frydman R, Maurel MC | 2025 | First in class monoclonal antibody potentiating human follicle stimulating hormone activity improves spermatogenesis in azoospermic rodent models | Frontiers in endocrinology | In-vitro- und Tierversuch (Ratte, Maus) | Englisch | PMID 41163682 |
| s48 | Kaur J, Singhania N, Adhikari U, Vatsa R, Gorsi U, Bansal A, Bhadada S, Gupta N, Bhansali A, Sachdeva N, Kaushal A, Walia R | 2025 | Comparison of FSH Pre-treatment Versus Upfront hCG and FSH Regimens for Inducing Spermatogenesis in Congenital Hypogonadotropic Hypogonadism: A Pilot Study | Indian journal of endocrinology and metabolism | Randomisierte Pilotstudie · n=24 | Englisch | PMID 40688612 |
| s49 | Khashaba S, Khashaba S, Krishan A, Bruce A, Almaghlouth A, Huang J, Mima M, Niederberger C | 2025 | Efficacy of clomiphene citrate and tamoxifen on pregnancy rates in idiopathic male subfertility: A systematic review and meta-analysis | Asian journal of urology | Systematische Übersicht und Metaanalyse (RCT) | Englisch | PMID 39990067 |
| s50 | Li J, Li K, Zhang M, Chen J, Chen M, Dong W, Yu W, Lei L, Huang Y, Yang H, Ren P, Zou Q, Deng L. | 2025 | Male Infertility Management: A Critical Appraisal of Clinical Practice Guidelines With the AGREE II Instrument. | American journal of men's health 19:15579883251380203 | Systematische Leitlinienbewertung (AGREE II) · n=10 Leitlinien | Englisch | PMID 41025162 |
| s51 | Liberto R, Katlowitz N, Sagalovich D, Davila J | 2025 | Strategies for Reversing Exogenous Testosterone-Induced Infertility | Cureus | Übersichtsarbeit | Englisch | PMID 41080372 |
| s52 | Nariyoshi S, Nakano K, Sukegawa G, Tsuji Y. | 2025 | Alterations in the ultrasound appearance of seminiferous tubules after gonadotropin treatment in patients with azoospermia because of hypogonadotropic hypogonadism. | F&S reports 6:428-435 | Retrospektive Beobachtungsstudie · n=10 Männer | Englisch | PMID 41473567 |
| s53 | Nokhbeh Zaeem S, Heydari Nasrabadi M, Salehipour M, Ehtesham S | 2025 | Letrozole and Crocin: Protecting Leydig Cells and Modulating Androgen Receptor and CYP19 Gene Expression in Busulfan-Induced Azoospermia | Animals : an open access journal from MDPI | Tierversuch (Ratte) · n=30 | Englisch | PMID 40075978 |
| s54 | Pelit ES, Danacıoğlu YO, Katı B | 2025 | Comparison of Effects of Chorionic Gonadotropin Alfa and Anastrozole on Sperm Retrieval Rate in Patients with Non-Mosaic Klinefelter Syndrome Following Microdissection Testicular Sperm Extraction | Medicina (Kaunas, Lithuania) | Retrospektive Vergleichsstudie · n=43 | Englisch, Türkisch | PMID 40142278 |
| s55 | Rozhivanova ER, Rozhivanov RV, Andreeva EN et al. | 2025 | [Restoration of ejaculate quality following androgen replacement and combined therapy for hypogonadism]. (deutsch: Wiederherstellung der Ejakulatqualität nach Androgenersatz und nach kombinierter Therapie bei Hypogonadismus) | Problemy endokrinologii | Prospektive Beobachtungsstudie · n=53 | Russisch | PMID 41014618 |
| s56 | Santi D, Corona G, Salonia A, Ferlin A | 2025 | Current drawbacks and future perspectives in the diagnosis and treatment of male factor infertility, with a focus on FSH treatment: an expert opinion | Journal of endocrinological investigation | Expertenmeinung/Übersichtsarbeit | Englisch | PMID 39804439 |
| s57 | Santi D, Pallotti F, Tienforti D, Spaggiari G, Barbonetti A | 2025 | Empirical hormonal treatments for idiopathic male infertility: a network meta-analysis comparing antiestrogens and FSH | European journal of endocrinology | Netzwerk-Metaanalyse · n=1676 | Englisch | PMID 41347881 |
| s58 | Sheng H, Liang C, Cheng J, Liu H, Mao X, Li X, Li D, Lu Z, Cai Y, Su X, Zhang L, Fu W, Hu J, Jia W, Liu G, Zhang W, Liu L, Lin Y. | 2025 | Clinical characteristics, genetic spectrum and therapeutic effects of 51 male patients with idiopathic hypogonadotropic hypogonadism from southern China. | Orphanet journal of rare diseases 20:574 | Retrospektive Kohorte · n=51 Männer (34 behandelt) | Englisch | PMID 41225491 |
| s59 | Shoaib H, Duffy J, Ahmed K | 2025 | Use of Human Chorionic Gonadotropin (HCG) or HCG-Combined Treatments in Male Infertility: A Systematic Review | Cureus | Systematische Übersicht (RCT) · n=926 | Englisch | PMID 41210019 |
| s60 | Shukla J, Moni SN, Hasan MM, Islam MA, Shikha AN, Jahan NW, Ishrat S | 2025 | Clomiphene citrate improves sperm parameters in infertile men with idiopathic oligoasthenozoospermia | Clinical and experimental reproductive medicine | Randomisierte kontrollierte Studie · n=50 | Englisch | PMID 40899280 |
| s61 | Smit DL, Verdegaal T, Bond P | 2025 | Efficacy of human chorionic gonadotropin hormone in restoring spermatogenesis in men using non-prescribed androgens: a retrospective analysis of real-world data | F&S reports | Retrospektive Analyse · n=19 | Englisch | PMID 40620361 |
| s62 | Stocks BT, Oppenheimer AG, Campbell KJ, Lindsey JP, Kohn TP, Alexander JM, Huang JB, Lipshultz LI | 2025 | Optimal restoration of spermatogenesis after testosterone therapy using human chorionic gonadotropin and follicle-stimulating hormone | Fertility and sterility | Retrospektive Kohortenstudie · n=77 | Englisch | PMID 39442683 |
| s63 | Szabó A, Váncsa S, Hegyi P, Kói T, Ács J, Hermánné RJ, Ács N, Szarvas T, Nyirády P, Kopa Z | 2025 | Assessing the efficacy of varicocelectomy, antioxidants, FSH treatment, and lifestyle modifications on sperm DNA fragmentation: a systematic review and meta-analysis | Scientific reports | Systematische Übersicht und Metaanalyse (DNA-Fragmentation) | Englisch | PMID 40128318 |
| s64 | Tsujimura A, Iijima M, Umemoto Y, Kobayashi H, Komiya A, Shiraishi K, Chiba K, Hirota Y, Fukuhara S, Yumura Y. | 2025 | Summary of the Clinical Practice Guidelines for Male Infertility by the Japanese Urological Association With the Support of the Japan Society for Reproductive Medicine. | International journal of urology : official journal of the Japanese Urological Association 32:1301-1313 | Zusammenfassung einer klinischen Leitlinie · n=Leitlinie | Englisch | PMID 40459122 |
| s65 | Ullur P, Kubera NS, Manikandan S, Nanda N, Venkatraman S, Ram A | 2025 | Efficacy and Safety of Letrozole in Improving Semen Parameters of Subfertile Men with Moderate-to-Severe Oligoasthenoteratozoospermia: A Placebo-controlled Randomised Trial | Journal of human reproductive sciences | Randomisierte placebokontrollierte Doppelblindstudie · n=54 | Englisch | PMID 40342887 |
| s66 | Wren J, Myre B, Halpern JA, Panken E, Bennett NE, Brannigan RE | 2025 | Safety of Clomiphene Citrate and Its Impact on Serum Tumor Markers in Hypogonadal Testicular Cancer Patients After Chemotherapy | Cureus | Retrospektive Aktenanalyse · n=10 | Englisch | PMID 41378263 |
| s67 | Wydra J, Wydra A, Kucharczyk P, Kapuściński G, Zgliczyński W, Rabijewski M | 2025 | Selective estrogen receptor modulators and aromatase inhibitors in the treatment of functional male hypogonadism | Endokrynologia Polska | Übersichtsarbeit | Englisch | PMID 40892389 |
| s68 | Yoo JE, Kim YK, Kim JY, Cho KW, Kim SJ, Kim S, Choi Y, Song K, Lee EB, Chae HW, Suh J. | 2025 | Comparison of Gonadotropin and Testosterone Therapy in Adolescent Males with Hypogonadotropic Hypogonadism. | Hormone research in paediatrics:1-11 | Retrospektive Kohorte · n=70 Jugendliche | Englisch | PMID 41442431 |
| s69 | Zheng Y, Bai HZ, Zhao GC, Tian K, Yue JT, Li DM, Jiang XH | 2025 | Comparison of outcomes between pulsatile gonadotropin releasing hormone and combined gonadotropin therapy of spermatogenesis in patients with congenital hypogonadotropic hypogonadism | Reproductive biology and endocrinology : RB&E | Retrospektive Kohortenstudie · n=155 | Englisch | PMID 40119359 |
| s70 | Adel O, El-Sherbiny HR, Shahat AM, Ismail ST | 2024 | Effect of a single dose of letrozole on ejaculation time, semen quality, and testicular hemodynamics in goat bucks subjected to heat stress | Veterinary research communications | Tierversuch (Ziegenböcke) · n=12 | Englisch, Arabisch | PMID 39382810 |
| s71 | Al Wattar BH, Rimmer MP, Teh JJ, Mackenzie SC, Ammar OF, Croucher C, Anastasiadis E, Gordon P, Pacey A, McEleny K, Sangster P | 2024 | Pharmacological non-hormonal treatment options for male infertility: a systematic review and network meta-analysis | BMC urology | Systematische Übersicht und Netzwerk-Metaanalyse (RCT) · n=1342 | Englisch | PMID 39075435 |
| s72 | Alexander EC, Faruqi D, Farquhar R, Unadkat A, Ng Yin K, Hoskyns R, Varughese R, Howard SR | 2024 | Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis | European journal of endocrinology | Systematische Übersicht und Metaanalyse (Pubertätsinduktion) · n=5328 | Englisch | PMID 38128110 |
| s73 | Bozhedomov V A, Korneev I A, Kamalov A A | 2024 | [Deterioration of male reproductive function: methods and algorithms of etiopathogenetic and empirical treatment of the main clinical forms]. (deutsch: Verschlechterung der männlichen Fortpflanzungsfunktion: Methoden und Algorithmen der ätiopathogenetischen und empirischen Behandlung der wichtigsten klinischen Formen) | Urologiia (Moscow, Russia : 1999) | Übersichtsarbeit (Algorithmus) · n=k. A. | Russisch | PMID 39564856 |
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| s85 | Mogheiseh A, Derakhshandeh N, Divar MR, Nazifi S, Ahmadi I | 2024 | Effects of short-term oral letrozole on fresh semen parameters, endocrine balance, and prostate gland dimensions in domestic dogs | BMC veterinary research | Tierversuch (Hund) · n=7 | Englisch | PMID 39289700 |
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| s98 | Kim D, Lee S, Cho YH, Kang MJ, Ku CR, Chi H, Ahn J, Lee K, Han J, Chi S, Song MY, Cha SH, Lee EJ. | 2023 | Long-acting recombinant human follicle-stimulating hormone (SAFA-FSH) enhances spermatogenesis. | Frontiers in endocrinology 14:1132172 | Tierversuch (Ratte) und Zellversuch · n=nicht in der Zusammenfassung angegeben | Englisch | PMID 36909328 |
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| s102 | Naelitz BD, Jiang T, Munoz-Lopez C, Sigalos JT, Modiri N, Cannarella R, Mills JN, Parekh N, Nowacki AS, Vij SC, Eleswarapu SV, Lundy SD | 2023 | Testosterone and luteinizing hormone predict semen parameter improvement in infertile men treated with anastrozole | Fertility and sterility | Retrospektive Kohortenstudie (multizentrisch) · n=90 | Englisch | PMID 37392782 |
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| s107 | Andrabi SW, Makker GC, Makker R, Mishra G, Singh R | 2022 | Human chorionic gonadotropin therapy in hypogonadic severe-oligozoospermic men and its effect on semen parameters | Clinical and experimental reproductive medicine | Interventionsstudie (einarmig) · n=56 | Englisch | PMID 35255659 |
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| s112 | Hmood Jassim A, Abed AS, Kareem Thamer A, Judi HK, Enad AH | 2022 | Effect of Letrozole Administration as a Selective Aromatase Inhibitor on Male Rat's Reproductive Performance | Archives of Razi Institute | Tierversuch (Ratte) · n=40 | Englisch, Arabisch | PMID 35891754 |
| s113 | Jiang T, Osadchiy V, Santamaria A, Zheng MH, Modiri N, Sigalos JT, Regets KV, Mills JN, Eleswarapu SV | 2022 | Initial gonadotropin levels and sperm parameters differentiate the response to clomiphene citrate in subfertile men | Translational andrology and urology | Retrospektive Analyse · n=137 | Englisch | PMID 35280658 |
| s114 | Liao Y, Chang YK, Wang SM, Chang HC | 2022 | Ceiling effect of clomiphene citrate on the testosterone to estradiol ratio in eugonadal infertile men | PloS one | Prospektive Beobachtungsstudie · n=24 | Englisch | PMID 35100304 |
| s115 | Pajai S, Potdar J, Gopal U, Banait T | 2022 | A Review on the Use of Letrozole in Female and Male Infertility | Cureus | Übersichtsarbeit | Englisch | PMID 36514610 |
| s116 | Peng T, Liao C, Ye X, Chen Z, Lan Y, Fu X, An G. | 2022 | Gonadotropins treatment prior to microdissection testicular sperm extraction in non-obstructive azoospermia: a single-center cohort study. | Reproductive biology and endocrinology : RB&E 20:61 | Retrospektive Kohorte (mit IPTW) · n=569 Männer | Englisch | PMID 35365173 |
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| s119 | Tharakan T, Corona G, Foran D, Salonia A, Sofikitis N, Giwercman A, Krausz C, Yap T, Jayasena CN, Minhas S | 2022 | Does hormonal therapy improve sperm retrieval rates in men with non-obstructive azoospermia: a systematic review and meta-analysis | Human reproduction update | Systematische Übersicht und Metaanalyse · n=1706 | Englisch | PMID 35526153 |
| s120 | Türkmen NB, Çiftçi O, Taşlıdere A et al. | 2022 | The effect of aromatase inhibitors against possible testis toxicity in pembrolizumab treated rats. | Andrologia | Tierversuch (Ratte) · n=42 | Türkisch, Englisch | PMID 36177829 |
| s121 | Yang Y, Chen S, Chen H, Guo Y, Teng X | 2022 | The efficacy of anastrozole in subfertile men with and without abnormal testosterone to estradiol ratios | Translational andrology and urology | Retrospektive Studie · n=105 | Englisch | PMID 36217397 |
| s122 | Yao Y, Wan Y, Shi X, Guo L, Jiang H, Zhang X, Xu B, Hua J | 2022 | Letrozole protects against cadmium-induced inhibition of spermatogenesis via LHCGR and Hsd3b6 to activate testosterone synthesis in mice | Reproductive biology and endocrinology : RB&E | Tierversuch (Maus) · n=nicht in der Zusammenfassung angegeben | Englisch | PMID 35236366 |
| s123 | Zhang X, Chen J, Cui Y, Jin Y, Wang X. | 2022 | FSH can improve semen parameters in patients with idiopathic oligoasthenoteratozoospermia: A systematic review and meta-analysis. | Andrologia 54:e14596 | Systematische Übersicht mit Metaanalyse · n=13 Studien, 924 Personen | Englisch | PMID 36104938 |
| s124 | Akomolafe SF, Aina B, Bajulaye J, Ogundare I, Olulade D, Adeniji R, Fatuase F, Olojo-Kosoko A, Ganiyu O, Asogwa NT | 2021 | Modulatory effect of cashew (Anacardiumoccidentale L.) nut supplemented diet on fertility activity of clomiphene citrate in male rats | Biomedical journal | Tierversuch (Ratte) | Englisch | PMID 33451960 |
| s125 | Alrabeeah K, Addar A, Alothman A, Melha SA, Alkhayal A | 2021 | Effect of hormonal manipulation using clomiphene citrate prior to microdissection testicular sperm retrieval | Urology annals | Retrospektive Studie · n=122 | Englisch, Arabisch | PMID 34421260 |
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| s128 | Condorelli RA, Cannarella R, Crafa A, Barbagallo F, Mongioì LM, Aversa A, Greco E, Calogero AE, La Vignera S | 2021 | Retrospective Monocentric Clinical Study on Male Infertility: Comparison between Two Different Therapeutic Schemes Using Follicle-Stimulating Hormone | Journal of clinical medicine | Retrospektive monozentrische Studie · n=48 | Englisch | PMID 34204212 |
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| s131 | Huyghe E, Boitrelle F, Methorst C, Mieusset R, Ray PF, Akakpo W, Koscinski I, Chalas C, Rives N, Plotton I, Robin G, El Osta R, Hennebicq S, Eustache F, Marcelli F, Lejeune H | 2021 | [AFU and SALF recommendations for the evaluation of male infertility] (deutsch: AFU- und SALF-Empfehlungen zur Abklärung der männlichen Infertilität) | Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie | Leitlinie (AFU/SALF, Diagnostik der männlichen Infertilität) | Französisch | PMID 33309127 |
| s132 | Muhammed Arif İBİŞ, Kaan AYDOS | 2021 | Evaluation of gonadotropin therapy in male infertility caused by idiopathic hypogonadotropic hypogonadism / İdiopatik hipogonadotropik hipogonadizm nedenlierkek infertilitesinde gonadotropin tedavisinindeğerlendirilmesi (deutsch: Bewertung der Gonadotropintherapie bei männlicher Infertilität durch idiopathischen hypogonadotropen Hypogonadismus) | Androloji Bülteni | Retrospektive Kohortenstudie · n=60 | Türkisch, Englisch | DOI |
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Alle Kapitel und Anhänge (26)
- Das Wichtigste in Kürze
- Aufbau und Methodik dieser Studie
- Hintergrund
- Übersicht der Metaanalysen und systematischen Übersichten bis Hypogonadotroper Hypogonadismus (HH)
- Hypogonadismus (Testosteronmangel) und SERM: indirekt fertilitätsrelevante Übersichten bis Zusammenschau der Metaanalysen und Übersichten
- Hypogonadotroper Hypogonadismus: westliche, australische und türkische Kohorten bis Hypogonadotroper Hypogonadismus: Japan, Korea, Taiwan und weitere Länder
- Nicht-obstruktive Azoospermie: Hormonvorbehandlung und Salvage-Therapie bei Beobachtungsstudien bis Idiopathische und unerklärte Oligo-, Astheno- und Teratozoospermie: Aromatasehemmer
- Idiopathische Oligo-, Astheno- und Teratozoospermie: FSH, hMG, hCG und Kombinationen bis Zusammenschau der Beobachtungsstudien
- Vorbemerkung zu Grundlage und Grenzen bis Clomifen, Tamoxifen und Enclomiphen
- Aromatasehemmer (Letrozol, Anastrozol, Testolacton) bis Hypogonadotroper Hypogonadismus: Gonadotropine und GnRH-Pumpe
- Nicht-obstruktive Azoospermie: Hormonvorbehandlung vor der Spermiengewinnung bis Einordnung der Studienlage und Besonderheiten der Quellenräume
- Mechanismen und biologische Plausibilität
- Dosis-Wirkung, Subgruppen und Reversibilität
- Englisch bis Chinesisch
- Japanisch bis Türkisch
- Widersprüche und ihre mögliche Erklärung
- Limitationen der Evidenz
- Offene Forschungsfragen
- Praktische Einordnung
- Glossar
- Quellenverzeichnis (Teil 1 von 2)
- Quellenverzeichnis (Teil 2 von 2)
- Diagramme
- Quellen s01–s133
- Quellen s134–s263
- Prüfprotokoll der Quellenkontrolle